Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases
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چکیده
Ulrich Laufs, Karen Gertz, Paul Huang, Georg Nickenig, Michael Böhm, Ulrich Dirnagl and Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.31.10.2442 2000;31:2442-2449 Stroke. http://stroke.ahajournals.org/content/31/10/2442 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice.
BACKGROUND AND PURPOSE Thrombosis superimposed on atherosclerosis causes approximately two thirds of all brain infarctions. We previously demonstrated that statins protect from cerebral ischemia by upregulation of endothelial type III nitric oxide synthase (eNOS), but the downstream mechanisms have not been determined. Therefore, we investigated whether antithrombotic effects contribute to stro...
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OBJECTIVE Statins decrease mortality in patients with vascular disorders, and evidence for the pleiotropic effects of statins is accumulating. Statins enhance endothelial NO synthase (eNOS) expression, thereby attenuating platelet activation and thrombus formation. Our goal was to determine whether statins have eNOS-independent effects on platelet activation. METHODS AND RESULTS Wild-type and...
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OBJECTIVE Three-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are known to enhance vascular expression of endothelial (eNOS) and inducible nitric oxide synthase (iNOS). In this study, we examined whether statins also upregulate vascular expression of neuronal NOS (nNOS). METHODS AND RESULTS In cultured rat aortic smooth muscle cells, treatment with atorvastatin ...
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Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...
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Background: Nitric oxide synthase (NOS) activity is increased during hypertension and cerebral ischemia. NOS inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (BBB) disruption and cerebral edema formation during stroke in acute hypertension. Here, we investigated the role of NOS inhibition in progression of edema formation and BBB d...
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